MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Depressive symptoms and increased visceral fat in middle-aged women.

Citation Type: Journal Article

Publication Year: 2009

ISSN: 1534-7796

DOI: 10.1097/PSY.0b013e3181a20c9c

PMID: 19398501

Abstract: OBJECTIVE To examine whether depressive symptoms are differentially associated with visceral adipose tissue (VAT), which is more metabolically active and confers greater cardiovascular risk than subcutaneous fat (SAT). Prior research has shown an association between depression and central adiposity. Mechanisms underlying the association between depression and increased cardiovascular risk remain poorly understood. Central adiposity is one potential pathway. METHODS We investigated the cross-sectional association between depressive symptoms, assessed by the Center for Epidemiological Studies Depression Scale (CES-D), and VAT and SAT, assessed by computed tomography, in a sample of 409 middle-aged women (44.7% African-Americans, 55.3% Whites; mean age = 50.4 years) participating in the Chicago site of the Study of Women's Health Across the Nation (SWAN). RESULTS With adjustments for age, race, total percent fat, and sex hormone binding globulin (SHBG), each 1-point higher score on the CES-D was associated with 1.03-cm(2) greater VAT (p < .001). Women with a CES-D score of >or=16, indicative of clinically relevant depressive symptomatology, had 24.5% more VAT than women with lower CES-D scores (p < .001). Further adjustment for Framingham Risk Score and physical activity did not alter the findings, and associations did not vary by race. Associations were strongest in obese and overweight women. Depressive symptoms were unrelated to SAT. CONCLUSIONS Increased visceral fat may be one pathway by which depression contributes to excess risk for cardiovascular disease and diabetes. Further research is needed to examine whether depressive symptoms influence accumulation of VAT over time.

Url: http://www.ncbi.nlm.nih.gov/pubmed/19398501

Url: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC2739059

User Submitted?: No

Authors: Everson-Rose, Susan A; Lewis, Tené T; Karavolos, Kelly; Dugan, Sheila A; Wesley, Deidre; Powell, Lynda H

Periodical (Full): Psychosomatic medicine

Issue: 4

Volume: 71

Pages: 410-6

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop