MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Periodontal disease and incident dementia: The Atherosclerosis Risk in Communities Study (ARIC)

Citation Type: Journal Article

Publication Year: 2020

ISSN: 1526632X

DOI: 10.1212/WNL.0000000000010312

PMID: 32727837

Abstract: OBJECTIVE: To test the hypothesis that periodontal disease would be associated with increased risk for dementia and mild cognitive impairment (MCI) by assessing dementia/MCI outcomes after a baseline periodontal examination. METHODS: Participants enrolled in the Atherosclerosis Risk in Communities study with a clinical periodontal examination (or edentulous participants) at visit 4 (1996-1998; mean ± SD age 63 ± 6 years, 55% female, 21% black) and adjudicated dementia outcomes through 2016 were included (n = 8,275). A subgroup of 4,559 participants had adjudicated dementia and MCI assessments at visit 5 (2011-2013). Participants received a full-mouth periodontal examination and were classified into periodontal profile classes (PPCs) based on the severity and extent of gingival inflammation and attachment loss. MCI and dementia were determined via neurocognitive testing, neurological examination and history, informant interviews, and brain MRI in a subset. Cox proportional hazards models regressed incident dementia on PPCs. Relative risk regression models were used for the composite of MCI/dementia. RESULTS: The cumulative incidence and incidence density of dementia during follow-up (average 18.4 years) were 19% (n = 1,569) and 11.8 cases per 1,000 person-years. Multivariable adjusted hazard ratios for incident dementia among participants with severe PPC or edentulism (vs periodontal healthy) were 1.22 (95% confidence interval [CI] 1.01-1.47) and 1.21 (95% CI 0.99-1.48), respectively. For the combined dementia/MCI outcome, adjusted risk ratios among participants with mild/intermediate PPC, severe PPC, or edentulism (vs periodontal healthy) were 1.22 (95% CI 1.00-1.48), 1.15 (95% CI 0.88-1.51), and 1.90 (95% CI 1.40-2.58). Results were stronger among younger (≤62 years) participants (p for interaction = 0.02). CONCLUSION: Periodontal disease was modestly associated with incident MCI and dementia in a community-based cohort of black and white participants.

Url: https://pubmed.ncbi.nlm.nih.gov/32727837/

User Submitted?: No

Authors: Demmer, Ryan T.; Norby, Faye L; Lakshminarayan, Kamakshi; Walker, Keenan A.; Pankow, James S; Folsom, Aaron R; Mosley, Thomas H.; Beck, Jim; Lutsey, Pamela L.

Periodical (Full): Neurology

Issue: 12

Volume: 95

Pages: e1660-e1671

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop