MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Immune-related conditions and acute leukemia in children with Down syndrome: a Children's Oncology Group report.

Citation Type: Book, Whole

Publication Year: 2015

ISBN: 1538-7755 (Electronic)\r1055-9965 (Linking)

ISSN: 1538-7755

DOI: 10.1158/1055-9965.EPI-14-1181

PMID: 25499068

Abstract: BACKGROUND: Children with Down syndrome have unique immune profiles and increased leukemia susceptibility.\n\nMETHODS: Mothers of 158 children with Down syndrome diagnosed with acute leukemia at 0 to 19 years in 1997 to 2002 and 173 children with Down syndrome but no leukemia were interviewed. Associations were evaluated via multivariable unconditional logistic regression.\n\nRESULTS: No associations were detected for asthma, eczema, allergies, or hypothyroidism. Diabetes mellitus associated with leukemia (OR = 9.23; 95% confidence interval 2.33-36.59); however, most instances occurred concurrent with or after the leukemia diagnosis.\n\nCONCLUSIONS AND IMPACT: Children with Down syndrome who develop leukemia have increased diabetes risk, likely due to treatment and underlying susceptibility factors.

Url: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4323733&tool=pmcentrez&rendertype=abstract

User Submitted?: No

Authors: Linabery, Amy M.; Li, Wenchao; Roesler, Michelle; Spector, Logan G.; Gamis, Alan S; Olshan, Andrew F.; Heerema, Nyla A.; Ross, Julie A.

Publisher:

Publisher Location:

Pages: 454-8

Volume: 24

Edition:

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IPUMS NHGIS NAPP IHIS ATUS Terrapop