MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: Maternal health conditions during pregnancy and acute leukemia in children with Down syndrome: A Children's Oncology Group study.

Citation Type: Book, Whole

Publication Year: 2009

ISSN: 1545-5017

DOI: 10.1002/pbc.21914

PMID: 19148952

Abstract: BACKGROUND: Children with Down syndrome (DS) have about a 20-fold increased risk of developing leukemia. Early childhood infections may protect against acute lymphoid leukemia (ALL) in children with and without DS. We examined whether maternal infections and health conditions during pregnancy were associated with acute leukemia in children with DS.\n\nPROCEDURE: We conducted a case-control study of 158 children with DS and leukemia (including 97 cases with acute lymphoblastic leukemia (ALL) and 61 cases with acute myeloid leukemia (AML)) and 173 children with DS during the period 1997-2002. Maternal interview included information about 14 maternal conditions during gestation that are likely to induce an inflammatory response. We evaluated their prevalence in cases and controls. Five of these were common enough to allow analyses by leukemia subtype.\n\nRESULTS: Vaginal bleeding was the most frequent (18% cases, 25% controls) and was associated with a reduced risk (odds ratio (OR) = 0.57; 95% confidence interval (CI) = 0.33-0.99) for all cases combined. Other variables, while showing a potential trend toward reduced risk had effect estimates, which were imprecise and not statistically significant. In contrast, amniocentesis was marginally associated with an increased risk of AML (OR = 2.06, 95% CI = 0.90-4.69).\n\nCONCLUSIONS: Data from this exploratory investigation suggest that some health conditions during pregnancy may be relevant in childhood leukemogenesis. Larger epidemiological studies and other model systems (animal, clinical studies) may provide a clearer picture of the potential association and mechanisms.

Url: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2659730&tool=pmcentrez&rendertype=abstract

User Submitted?: No

Authors: Ognjanovic, Simona; Puumala, Susan E.; Spector, Logan G.; Smith, Franklin O.; Robison, Leslie L.; Olshan, Andrew F.; Ross, Julie A.

Publisher:

Publisher Location:

Pages: 602-8

Volume: 52

Edition:

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop