Full Citation
Title: Estimating the cognitive effects of prevalent diabetes, recent onset diabetes, and the duration of diabetes among older adults
Citation Type: Journal Article
Publication Year: 2015
ISBN:
ISSN: 1421-9824; 1420-8008
DOI: 10.1159/000368654 [doi]
NSFID:
PMCID:
PMID: 25613323
Abstract: BACKGROUND: Little evidence is available on the effects of incident diabetes or diabetes duration on cognitive aging. METHODS: We evaluated the effects of prevalent and incident diabetes on deteriorations in cognitive function, based on participants (n = 8,671) aged 65+ in the Health and Retirement Study in 2000. Inverse probability weighting was used to account for selective attrition and time-varying confounding of incident diabetes. RESULTS: Prevalent diabetes predicted higher odds of dementia [odds ratio 1.27; 95% confidence interval (CI) 1.03-1.58] and worse memory (-0.06 in z-score units; 95% CI -0.10 to -0.02), but incident diabetes or diabetes duration up to 8 years of follow-up was not predictive. CONCLUSION: Prevalent diabetes predicted lower cognition but not recent onset diabetes.
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Authors: Wu, Qiong; Tchetgen, Eric J; Osypuk, Theresa L; Weuve, J; White, Kellee; Mujahid, M; Glymour, M Maria
Periodical (Full): Dementia and geriatric cognitive disorders
Issue: 3-4
Volume: 39
Pages: 239-487
Countries: