MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: 0546 Sleep Medication Use Trajectories over 30 Years and Late-Life Hearing Loss

Citation Type: Journal Article

Publication Year: 2025

ISSN: 0161-8105

DOI: 10.1093/SLEEP/ZSAF090.0546

Abstract: SLEEP, Volume 48, Supplement 1, 2025 95%CI=0.53,0.68; p< 0.0001], and control [HR=0.68, 95%CI=0.60,0.77; p< 0.0001]. Similarly, TCA was associated with lower mortality risk compared to Z-drugs [HR=0.90, 95%CI=0.88,0.93; p< 0.0001], MLT [HR=0.71, 95%CI=0.69, 0.73; p< 0.0001], BNZ [HR=0.86, 95%CI=0.83, 0.88; p< 0.0001], and control [HR=0.86, 95%CI=0.84,0.88; p< 0.0001]. Z-drugs were associated with lower mortality risk compared to MLT [HR=0.77, 95%CI=0.74, 0.77; p< 0.0001], and BNZ [HR=0.93, 95%CI=0.92,0.95; p< 0.0001] but no difference to control [HR=0.99, 95%CI=0.98, 1.02; p=0.915]. However, treatment with MLT or BNZ was associated with an increased mortality risk compared to control [HR=1.27, 95%CI=1.25,1.29; p< 0.0001], [HR=1.06, 95%CI= 1.05,1.08; p< 0.0001], respectively. MLT was associated with higher mortality risk compared to BNZ [HR=1.19, 95%CI=1.18,1.21; p< 0.0001]. Conclusion: In this retrospective study, treatment with orexin receptor agonists was associated with a more favorable survival compared to other insomnia medications in patients with HF and insomnia. Future randomized controlled studies are warranted to confirm these findings. Introduction: Evidence regarding the potential adverse impact of sleep medications on hearing is inconsistent and limited. Potential mechanisms include decreased input from the auditory nerve and disturbed organization and integration of sensory information. This study aims to investigate the associations between trajectories of sleep medication use over nearly 30 years and late-life hearing among community-dwelling adults. Methods: Participants in the Atherosclerosis Risk in Communities (ARIC) Study underwent hearing evaluations at visit 6 (2016-17) and provided medications used in the past four weeks for each visit from visits 1 (1987-89) to 6. Hearing outcomes included: (1) Peripheral auditory function: better-ear four-frequency (0.5, 1, 2, 4 kHz) pure-tone average (PTA, higher=worse) assessed by pure-tone audiometry in decibels (dB); (2) Central auditory function: Quick Speech-in-noise (QuickSIN) test measures the ability to understand speech in noise, with score ranging from 0-30

Url: https://dx.doi.org/10.1093/sleep/zsaf090.0546

User Submitted?: No

Authors: Jiang, Kening; Deal, Jennifer; Liu, Chunyu; Kaizi-Lutu, Marc; Lee, Angel; Full, Kelsie; Lutsey, Pamela; Morales, Emmanuel Garcia; Punjabi, Naresh; Reed, Nicholas; Wu, Mark; Lin, Frank; Gottesman, Rebecca; Spira, Adam; Hopkins Bloomberg, Johns

Periodical (Full): Sleep

Issue: Supplement_1

Volume: 48

Pages: A238-A238

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop