MPC Member Publications

This database contains a listing of population studies publications written by MPC Members. Anyone can add a publication by an MPC student, faculty, or staff member to this database; new citations will be reviewed and approved by MPC administrators.

Full Citation

Title: The prospective association between periodontal disease and brain imaging outcomes: The Atherosclerosis Risk in Communities study

Citation Type: Journal Article

Publication Year: 2022

ISSN: 1600-051X

DOI: 10.1111/JCPE.13586

PMID: 34905804

Abstract: Aim: We investigate if periodontal disease is prospectively associated with cerebrovascular and neurodegenerative markers of dementia and Alzheimer's pathology. Materials and Methods: N = 1306 participants (Visit 5 mean age = 76.5 [standard deviation = 5.4] years) in the Atherosclerosis Risk in Communities study with completed dental exams at Visit 4 underwent brain magnetic resonance imaging scans at Visit 5 while N = 248 underwent positron emission tomography scans. Participants were classified as edentulous or, among the dentate, by the modified Periodontal Profile Class. Brain volumes were regressed on periodontal status in linear regressions. Cerebrovascular measures and β-amyloid positivity were regressed on periodontal status in logistic regressions. Results: Periodontal disease was not associated with brain volumes, microhaemorrhages, or elevated β-amyloid. Compared with periodontally healthy individuals, odds ratios [95% confidence interval] for all-type infarcts were 0.37 [0.20, 0.65] for severe tooth loss and 0.56 [0.31, 0.99] for edentulous participants. Conclusions: Within the limitations of this study, periodontal disease was not associated with altered brain volumes, microhaemorrhages, or β-amyloid positivity. Tooth loss was associated with lower odds of cerebral infarcts.

Url: https://onlinelibrary.wiley.com/doi/full/10.1111/jcpe.13586

Url: https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpe.13586

Url: https://onlinelibrary.wiley.com/doi/10.1111/jcpe.13586

User Submitted?: No

Authors: Adam, Hamdi S.; Lakshminarayan, Kamakshi; Wang, Wendy; Norby, Faye L.; Mosley, Thomas; Walker, Keenan A.; Gottesman, Rebecca F.; Meyer, Katie; Hughes, Timothy M.; Pankow, James S.; Wong, Dean F.; Jack, Clifford R.; Sen, Souvik; Lutsey, Pamela L.; Beck, Jim; Demmer, Ryan T.

Periodical (Full): Journal of Clinical Periodontology

Issue: 4

Volume: 49

Pages: 322-334

Countries:

IPUMS NHGIS NAPP IHIS ATUS Terrapop